Reaper all the way. Why? Look at who you are giving your money to (and also, you can literally have a full version of Reaper for free for ever; the $60 is for a nonpro use license that you can just not pay, but I have paid it, because I support the way these guys do things).
- totally redesigned from the ground up; one of the newest DAWs on the market which means it is lean and efficient (vs bloated code); as far as I know it is the only one that you can run off a USB key and legally use on multiple workstations that way (they officially support that; none of this per machine or worse, the new trend in software, per core licensing - gouging the users)
- the above also means that it has a rather low CPU and RAM overhead to run it, so there's more comp horsepower for running more tracks with more plugz than other DAWs (Pro Tools is the worst for this, it's why they invented cards with their own CPUs dedicated to fx, cuz it was such a damn hog)
- designed by the guy who originally made WinAmp, which was solid software until he sold it to focus on developing Reaper
- the included plugs are good (esp the EQ and reverb) and it supports everything else you'd want to buy aftermarket - whatever you have now
- the free documentation and support ( forum) are second to none
- they actually listen to the forum community regarding how to improve the software
- not so possessive of information and code - many third party integrations (mostly for layout and look, to make it easier for people used to other DAWS, but also just to look cool)
I was a Cubase guy, now Reaper 4 eva. In another life (another forum), I convinced Guncho to try it. Full disclosure, I've never used S1. I have used Logic, Cakewalk/Sonar and a bit of Pro Tools however. Reaper is better than all of them. Pro Tools is the only other real choice IMHO and that's purely due to it's status as the pro inductry's standard (but most studio s also have Reaper, cuz so cheap and that's what a lot of their customers are bringing them... also I think there's a PT compatability export mode in Reaper, but I never learnt any more about it cuz I never needed it - might be wrong on that or maybe it's imperfect in some way ).