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I'm a huge fan of Graphtech, and have their nuts on all of my electric guitars - mainly for the lubrication properties. I used to have their saddles on about 90% of my guitars, but a couple of years ago, switched back to each respective stock saddle (along with some graphite lube that I made). My reasoning behind this was more aesthetics than anything, as Graphtech stuff can look out of place on certain guitars. I'd say that the only reason why you should switch to Graphtech or Tusq is if you break a lot of strings. Other than that, there's no huge audible difference.
With that said...In my experience, the difference is audible on an acoustic guitar. On an acoustic, I just noticed more sparkle when I switched from Tusq to bone. My wife's not a guitar player and even she noticed the differences. The first time I made that switch, I was instantly sold on bone, and all of my acoustics since have been outfitted with nuts and saddles that Bob Colosi have made for me. Well, worth the investment.
With that said...In my experience, the difference is audible on an acoustic guitar. On an acoustic, I just noticed more sparkle when I switched from Tusq to bone. My wife's not a guitar player and even she noticed the differences. The first time I made that switch, I was instantly sold on bone, and all of my acoustics since have been outfitted with nuts and saddles that Bob Colosi have made for me. Well, worth the investment.