OK, but the buffer thing as a solution to long unbalanced HiZ cable runs is overblown. It will help, but only to a point. Go over, say, 20' and same issue. The main thing that helps with is cuttting your overall length in half (i.e. at the pedal board) as regards distance before loss. If your pedalboard to amp cable (or inst to board for that matter) is over 20 ' then you still have a problem and nobody ios going to put a buffer pedal every 10' along the run because that's just gonna be annoying.
Best practice is:
1) keep cables short. Personally my instrument to pedal board cables are 6 feet (I am never on a big enough stage where I can move around much more than that) and my board to amp is 10'. There are bufferred pedals on my board; frackly, I think one would be hard pressed to find someone without at l;east 1 bufferred pedal (unless they were one of those people who specifically set out to do that with the whole True Bypass craze hit a few years back, but even then - who doesn't have a Boss pedal somewhere?).
2) It is better to use a long speaker cable (high power and LoZ means no problems with noise or signal loss over long runs) between amp and cab than to use a long instrument cable. This is particularly useful in the studio (play with the head in the control room so you can adjust yer tone/vol, run the speaker out onto the floor of the live room where it's miced up without your playing/fidgeting noise) but can also be applied live (especially with modern super-mini format heads units - put the head on your board and run a long speaker cable to the cab instead of instrument cable from the board to head on top of the cab with a short speaker cable).
3) when all else fails (e.g it's a combo not separate head/cab) and a long run is unavoidable, convert your instrument level signal (unbalanced HiZ as mentionned) to mic level (LoZ balanced) for the run, and back to instrument level at the receiving end. Devices to do this are available (see the Radial SGI system - the send/transmit box aka TX and the recieving box aka RX; any 2 passive DIs - backwards at the recieving end; watch your XLR cable gender as you'll need a converter or a fem to fem cable) or easy to DIY (transformer based is easiest and requires no power, but active solutions are more complex, but still pretty simple, and a lot cheaper) for about half the cost of the Radial SGI system (assuming transformers; cheaper still if basic active IC based device). With such a system you can run an instrument signal a few hundred feet without problems.