Absolutely. Brian's and Jack's point is that if you have a LOT of them, it can cause problems. Not always, if they are exceptionally well-designed. But most buffered pedals that employ e-switching, don't use anything that is predicated on preserving bandwidth in the face of 10 successive buffers. They do a very decent job in small quantities, mind you. And if that was all we used, that would be enough.
I think that both true-bypass and buffered e-switching have clear virtues. But, like a lot of things, one does not simply use them blindly as a panacea for everything. There are hurdles that TB nicely gets over, and hurdles that buffered bypass clears nicely too. Just gotta think about one's rig/chain as a whole, and use what suits each specific challenge.
An input buffer immediately after one's guitar is a good idea. I always recommend the following test. Take the longest gutar cable you have and plug your guitar directly into the amp with it. Now take the shortest cable you have (e.g., a pedal patch cord) and, without changing anything on the guitar or amp, plug your guitar directly into the amp using that one. The difference you'll hear in treble response is a product of cable capacitance and loading, curable by a suitable input buffer.
