From time to time, I futz around with my tweed Princeton, and stick a 6L6 in instead of the stock 6V6, and also pop the 5Y3 for a solid-state rectifier plug-in module, just for something different. The plate voltage is less than what a 6L6 wants, so there is no huge increment in output power. I've also experimented with lifting the negative feedback resistor for icepick-through-the-forehead tone. The combination of no feedback resistor, solid-state rectifier, and 6L6 gets a bit more output and more bark, less smooth.
The qualifier is that it's a single-ended amp. The nice thing is that everything is reversible.